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CASE REPORT
Year : 2015  |  Volume : 9  |  Issue : 4  |  Page : 162-163

Matched sibling allogenic transplant for an adult case of leukocyte adhesion deficiency (LAD-1)


1 Associate Professor, Gujarat Cancer and Research Institute, Ahmedabad, India
2 Resident Doctor, Gujarat Cancer and Research Institute, Ahmedabad, India
3 Professor, Gujarat Cancer and Research Institute, Ahmedabad, India

Correspondence Address:
Sandip A Shah
Associate Professor, Gujarat Cancer and Research Institute, Ahmedabad
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.ijt.2015.10.002

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We report first successful allogenic hematopoetic stem cell transplant of adult male with leukocyte adhesion deficiency. This patient was symptomatic for recurrent pyoderma gangrenosum since 10 years. He had received local treatments, systemic antibiotics, steroids, and cyclosporin but pyoderma was refractory leading to delay in hematopoetic stem cell transplant. The graft source was peripheral blood from 6/6 matched sibling. The conditioning regimen used was Busulphan, Cyclophosphamide, and antithymocyte globulin. Neutrophil engraftment occurred on day +14 and platelet engraftment occurred on day +24. Chimerism study of day +30 with VNTR showed 100% donor chimerism with normalization of CD18 expression.


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