• Users Online: 350
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2018  |  Volume : 12  |  Issue : 2  |  Page : 119-124

Prevalence and risk factors for posttransplant diabetes mellitus: Data from government tertiary care center


Department of Nephrology, Government Stanley Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. M Archana Balakrishnan
7/3, Shenbagavalli Street, Ayanavaram, Chennai - 600 023, Tamil Nadu
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijot.ijot_14_18

Get Permissions

Background: Diabetes occurs in substantial number of patients following renal transplantation, contributing to mortality and morbidity in particular the cardiovascular disease and infection. The prevalence and risk factors in South Indian population is not precisely clear. Our study aimed at determining the prevalence, epidemiology, and risk factors in kidney transplant recipients with posttransplant diabetes mellitus (PTDM). Methodology: This is a single-center analytical, cross-sectional, and retrospective study of adult renal transplant recipients who underwent transplant between January 2014 and December 2016. Institutional ethics committee approval was obtained. Results: Of 149 patients transplanted, 115 were included for study. Twenty-six patients (22.6%) developed PTDM. The mean age of the PTDM group was 35.2 years and 76.92% were males. Univariate analysis revealed age (P < 0.001), sex (P < 0.04), smoking (P = 0.02), history of diabetes mellitus (P < 0.001), dialysis vintage (P < 0.04), and induction therapy (P < 0.01) to be significant risk factors. The dosage of tacrolimus and prednisolone at the time of discharge and at months 3 & 6 post-transplant was significantly higher in PTDM group. Multivariate logistic regression analysis indicated age (odds ratio [OR] = 3.77), male gender (OR = 2.35), family history (OR = 4.54), dialysis vintage of >1 year (OR = 1.75), and induction therapy (OR = 2.0) to be independent risk factors for PTDM. Conclusions: There is high risk of developing diabetes after transplant with one quarter of this south Indian cohort developing PTDM. Older age, male sex, family history of diabetes, dialysis vintage, and use of induction therapy were independent risk factors for PTDM.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed339    
    Printed25    
    Emailed0    
    PDF Downloaded75    
    Comments [Add]    

Recommend this journal