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ORIGINAL ARTICLE
Year : 2018  |  Volume : 12  |  Issue : 3  |  Page : 177-181

ABO-incompatible renal transplantation: The journey so far on a road less traveled


1 Department of Nephrology, Fortis Escorts Hospital, New Delhi, India
2 Department of Nephrology, Medanta Institute of Kidney and Urology, Gurgaon, Haryana, India
3 Department of Pathology and Lab Medicine, Fortis Escorts Hospital, New Delhi, India
4 Department of Urology, Medanta Institute of Kidney and Urology, Gurgaon, Haryana, India

Correspondence Address:
Dr. Pranaw Kumar Jha
Department of Nephrology, Fortis Escorts Hospital, Okhla Road, New Delhi
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijot.ijot_23_18

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Introduction: ABO-incompatible (ABOi) renal transplant is the only option for patients who have neither blood group-compatible donors nor a suitable swap available. Published Indian experience of ABOi transplants has been far and few. Materials and Methods: This study was conducted across two different centers. All the consecutive ABOi renal transplants performed from November 2011 onward and who had completed at least 6 months of follow-up were included. Data were accessed retrospectively from the medical records. Results: There were fifty ABOi recipients who had completed at least 6 months of follow-up. Most common recipient blood group was group O. Median baseline antiblood group antibody titer (immunoglobulin G) was 256. Patient and death-censored graft survival were 94% and 88%, respectively, and biopsy-proven acute rejection was 22%. Acute antibody-mediated rejection was seen in 8% of the patients. Mean serum creatinine was 1.12 mg/dl at 1-month posttransplant and infection rate was 22%. Conclusion: The outcomes of ABOi transplant were acceptable and it should be promoted to bridge the demand and supply gap for renal transplant and expand the living donor pool.


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