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Year : 2019  |  Volume : 13  |  Issue : 2  |  Page : 130-133

Graft-versus-host disease: Rare complication postliver transplant

1 Department of Gastroenterology and Hepatology, Max Super Specialty Hospital, New Delhi, India
2 Department of Pathology, Max Super Specialty Hospital, New Delhi, India
3 Department of Hepatology, School of Digestive and Liver Disease, Institute of Postgraduate Medical Education and Research, SSKM Hospital, Kolkata, West Bengal, India
4 Center for Liver and Biliary Sciences, Max Super Specialty Hospital, New Delhi, India

Correspondence Address:
Dr. Nivedita Pandey
Department of Gastroenterology and Hepatology, Max Super Specialty Hospital, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijot.ijot_71_18

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Graft-versus-host disease (GVHD) following liver transplantation (LT) is an uncommon complication but has high mortality and represents a major diagnostic challenge. A 63-year-old male with nonalcoholic steatohepatitis-related decompensated cirrhosis underwent deceased donor LT. His postoperative course was complicated by fever, diarrhea, skin rashes, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Biopsies of the duodenum and skin were consistent with acute GVHD. This was confirmed by chimerism study performed on the bone marrow. The patient was treated with basiliximab, corticosteroids, tacrolimus, and mycophenolate; however, he had minimal response to intensive immunosuppressive therapy. The patient died due to multiorgan failure.

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