• Users Online: 316
  • Print this page
  • Email this page
Year : 2020  |  Volume : 14  |  Issue : 1  |  Page : 25-29

Short-term mineral metabolism adaptation in living kidney donors: A prospective study

1 Pramukhswami Medical College, Shree Krishna Hospital, Karamsad, Gujarat, India
2 Department of Medicine, MPUH, Nadiad, Gujarat, India

Correspondence Address:
Dr. Mital Dipakkumar Parikh
A-5 Vrundavan Park Soc, VIP Road, Karelibaug, Vadodara - 390 018, Gujarat
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijot.ijot_61_19

Get Permissions

Background: Living kidney donors (LKDs) show an abrupt decline in glomerular filtration rate (GFR) however, mineral metabolism adaptations in early chronic kidney disease (CKD) are still debated and not well studied in LKDs. We prospectively studied short term mineral metabolism adaptation of LKDs. Material and Methods: From January 2017 to April 2017, we included 36 adult LKDs. Their mineral parameters and renal function were repeatedly measured at days 0 and day 30 after kidney donation. Results: In the 1st month after nephrectomy, urinary phosphate reabsorption increased nonsignificantly in spite of significant increase in circulating fibroblast growth factor 23 (FGF23). LKDs have lower estimated GFR (eGFR) and unchanged 1,25-dihydroxyvitamin D (25(OH) 2D). Conclusion: Short-term mineral metabolism adaptations to decreased eGFR in donors include unchanged 25(OH) 2D unchanged fractional excretion of phosphate and increase in phosphate reabsorption with significant increase in FGF23. These adaptations differ from those described in CKD patients.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded39    
    Comments [Add]    

Recommend this journal