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ORIGINAL ARTICLE
Year : 2020  |  Volume : 14  |  Issue : 1  |  Page : 63-67

Survival after liver transplant in recipients older than 70 years: A systematic review and meta-analysis


1 Division of Gastroenterology and Hepatology, Mayo Clinic, Florida, USA
2 Department of Medicine, Bassett Medical Center, Cooperstown, New York, USA
3 Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA
4 Department of Medicine, Division of Nephrology, University of Mississippi Medical Center, Jackson, Mississippi, USA
5 Division of Transplant Surgery, Mayo Clinic, Jacksonville, Florida, USA
6 Department of Research and Development, Clinical Epidemiology Unit, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Correspondence Address:
Dr. Karn Wijarnpreecha
4500 San Pablo Road S, Jacksonville, FL 32224
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijot.ijot_59_19

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Background/Objectives: More elderly patients with end-stage liver disease are receiving liver transplantation. However, data on outcome of recipients older than 70 years are still limited. The current systematic review and meta-analysis was conducted with the aim to better describe the survival outcome of liver transplant in recipients older than 70 years compared to younger recipients. Methods: A comprehensive literature review was conducted utilizing the MEDLINE and EMBASE databases through March 2019 to identify all cohort studies that compared the long-term survival outcome between patients who underwent liver transplantation at age of >70 years versus younger recipients. Effect estimates from each study were extracted and combined together using the random-effects, generic inverse variance method of DerSimonian and Laird. Results: A total of 5 studies with 19,757 participants fulfilled the eligibility criteria and were included in the meta-analysis. The mortality rate was significantly increased among recipients who were 70 years or older compared to younger recipients with the pooled hazard ratio of 1.72 (95% confidence interval: 1.43–2.06; I2: 16%). Conclusions: The current study demonstrated a significantly increased risk of mortality postliver transplantation among recipients older than 70 years. This could be useful information to be considered along with other factors to establish graft allocation policy.


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