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CASE REPORT
Year : 2013  |  Volume : 7  |  Issue : 1  |  Page : 28-30

Clinical research on immunosuppressive drugs: The impact of new proposed organ donation guidelines


Assistant Professor, Department of Pharmacology, Hamdard Institute of Medical Sciences and Research and Associated Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi 110062, India

Correspondence Address:
Mohammed Imran
Assistant Professor, Department of Pharmacology, Hamdard Institute of Medical Sciences and Research and Associated Hakeem Abdul Hameed Centenary Hospital, Jamia Hamdard, New Delhi 110062
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.ijt.2012.11.001

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The release of National Institute of Health and Clinical Excellence guidelines for improving donor identification and consent rates and British Medical Association opinion regarding reintroduction of concept of ‘Elective Ventilation’ has started the debate in the realm of medical ethics. The concept of elective ventilation was earlier introduced by Royal Devon & Exeter Hospital in 1988 and finally declared unlawful by the Department of Health, United Kingdom in 1994 when ethical concerns were raised by the medical fraternity. Growth and development of safer and effective immunosuppressive drugs is hooked to the optimum number of cases of organ transplantation in research protocol. Toxic profile of these drugs and poor compliance has decreased their effectiveness. The drug discovery and development of safer immunosuppressants has been quite sluggish especially in last two decades. Very few randomised clinical trials have been performed in children and lesser subjects are being enrolled even in adult organ transplant clinical research. Without optimum number of clinical trial participants, it is difficult to extrapolate finding on larger population thus resulting in region specific divergent treatment protocols. Introduction of improved organ donation guidelines will enhance the number of cases of immunosuppressants used.


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