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ORIGINAL ARTICLE
Year : 2014  |  Volume : 8  |  Issue : 1  |  Page : 3-7

Pediatric renal transplantation: 5 years experience from Jaslok Hospital, Mumbai


1 Associate Consultant, Pediatric Nephrologist, Aditya Birla Memorial Hospital, Pune, Maharashtra, India
2 Consultant Urologist, Jaslok Hospital & Research Centre, Mumbai, Maharashtra, India
3 Consultant Pediatrician & Pediatric Nephrologist, Jaslok Hospital & Research Centre, Mumbai, Maharashtra, India

Correspondence Address:
Kiran P Sathe
Associate Consultant, Pediatric Nephrologist, Aditya Birla Memorial Hospital, Pune, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.1016/j.ijt.2014.01.016

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Objectives: To evaluate the patient characteristics, complications and outcome of renal transplantation in pediatric end stage renal disease (ESRD). Type of study: Retrospective observational analysis. Subjects: Children with ESRD subjected to renal transplantation in last 5 years (April 2007–March 2012) at Jaslok Hospital. Methods: Demographic data of the transplant recipients and donors, prior dialysis, surgical details of renal transplantation, immunosuppression, medical and surgical complications and post-transplant follow up and outcome was assessed. Results: 20 children in the age group 6–18 years (mean 14.6 years) underwent renal transplantation in last 5 years at our hospital. Fifteen percent cases (n = 3) weighed < 20 kg at transplantation. Primary cause of renal failure was glomerular in 30%, tubulo-interstitial in 45% and unknown in 25%. All were primary transplants, pre-emptive in 15%; live related in 95%, cadaveric in 5%. Mothers were the kidney donors in 60% cases. Induction therapy was used in 60% while maintenance therapy comprised of triple regimen. UTI was the commonest surgical complication (40%) followed by perinephric collection (20%), lymphocoele (15%) and renovascular thrombosis (10%, associated with graft dysfunction). 15% cases experienced graft rejection (acute cellular rejection (ACR), 66.6% and antibody mediated rejection (AMR), 33.3%) with complete renal recovery following treatment.73.4% and 72.8% cases had functioning grafts at the end of one and three years respectively. Conclusions: Pediatric renal transplantation was associated with 100% patient survival and is a safe therapeutic option for children with ESRD.


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