| ORIGINAL ARTICLE |
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| Year : 2014 | Volume
: 8
| Issue : 1 | Page : 8-11 |
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Serum trace elements before and 3 months after renal transplantation in kidney recipients: An Iranian study
Mohammad Reza Nikoobakht, Gholamreza Pourmand, Farzad Allameh, Hossein Dialameh, Amirsina Sharifi, Arsalan Hashemiaghdam
Urology Research Center, Sina Hospital, Tehran, Iran
Correspondence Address:
Hossein Dialameh
Urology Research Center, Sina Hospital, Tehran
Iran
 Source of Support: None, Conflict of Interest: None
DOI: 10.1016/j.ijt.2013.12.002
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Background: Decreased serum levels of trace elements seen in long-term hemodialysied patients, suppress immune system. The aim of this study was to find if any changes occur in trace elements after transplantation and assess the correlation between post-transplantation renal function and levels of trace elements.
Methods: Long-term hemodialysied patients with underlying ESRD were divided into two groups, who were undergone transplantation (n = 54) and were not (n = 69). Levels of lithium, magnesium, iron, zinc and copper measured 24 h before and three months after transplantation in both groups. The transplanted patients' serum levels of creatinine were assessed at same intervals as an indicator of graft function.
Results: 54 patients, 18 men (33%), 36 women (67%) with mean age of 47.67 ± 14.33 years underwent transplantation between April 2010 and April 2011. While serum iron (p < 0.001) and copper levels (p < 0.001) significantly increased after transplantation, there was a statistically significant reduction in magnesium levels (p < 0.001). No significant differences were noted in zinc (p = 0.17) and lithium (p = 0.080) levels in comparison to control group. A significant relationship was noted between levels of magnesium (p = 0.015) and zinc (p = 0.025) and creatinine within three months after transplantation.
Conclusion: Our study showed transplantation alters serum levels of trace elements in long-term hemodialysied patients with underlying ESRD and affects immunity and the results of renal function (Cr levels).
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