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Year : 2020  |  Volume : 14  |  Issue : 2  |  Page : 162-165

Posttransplant thrombotic microangiopathy: A rare cause

Department of Nephrology, Kilpauk Medical College, Chennai, Tamil Nadu, India

Correspondence Address:
Dr. Chaitanya Siva Marupudi
Room No. 40 KMC UG Men's Hostel, Kilpauk Medical College, Chennai - 600 010, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijot.ijot_13_20

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Parvovirus B19 is a common cause of aplastic anemia in immunosuppressed patients. However, renal involvement in cases of B19 infection is rare. The clinical presentation and histologic pattern of renal involvement due to parvovirus B19 infection has been described only in a few case reports. We report a patient with thrombotic microangiopathy (TMA) of graft kidney presumably secondary to B19 infection. The patient presented with severe anemia and allograft dysfunction following kidney transplantation. Kidney allograft biopsy was suggestive of TMA, and acute B19 infection was confirmed by the detection of viral DNA in the patient's serum. The patient had complete recovery following high-dose intravenous immunoglobulin therapy and reduction of immunosuppression.

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