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Year : 2020  |  Volume : 14  |  Issue : 3  |  Page : 243-246

Isolated B cell central nervous system posttransplant lymphoproliferative disorder: Role of magnetic resonance imaging in the diagnosis and management in the absence of neurological signs - a case report

1 Department of Radiology, Madras Medical Mission Hospital, Chennai, Tamil Nadu, India
2 Department of Nephrology, Madras Medical Mission Hospital, Chennai, Tamil Nadu, India
3 Department of Neurology, Madras Medical Mission Hospital, Chennai, Tamil Nadu, India
4 Department of Neurosurgery, Apollo Hospital, Chennai, Tamil Nadu, India
5 Department of Oncology, Apollo Hospital, Chennai, Tamil Nadu, India
6 Department of Pathology, Medical College Baroda and SSG Hospital, Vadodara, Gujarat, India

Correspondence Address:
Dr. Georgi Abraham
Madras Medical Mission Hospital, 4a, Dr. JJ Nagar, Mogappair, Chennai - 600 037, Tamil Nadu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijot.ijot_40_20

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A 29-year-old female who received a kidney from her mother 9 months ago, on minimal triple immunosuppression presented with short duration vertigo. There were no focal neurological deficits. Magnetic resonance imaging of the brain revealed peripherally enhancing periventricular lesions, predominantly in the bilateral frontal lobes. Positron-emission tomography showed increased uptake in the brain lesions. A stereotactic biopsy revealed CD20+ monomorphic B cell posttransplant lymphoproliferative disorder. The donor mother and daughter were Epstein–Barr virus (EBV) immunoglobulin G (IgG+)/IgG−. The cerebrospinal fluid and brain biopsy were positive for EBV. Treatment consisted of discontinuing prednisolone and MMF and reducing tacrolimus to 0.5 mg od. Rituximab, zidovudine, ganciclovir, and dexamethasone are being used. She has stable renal function.

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