• Users Online: 366
  • Print this page
  • Email this page
CASE REPORT
Year : 2020  |  Volume : 14  |  Issue : 4  |  Page : 346-348

A case report of ABO and human leukocyte antigen incompatible renal transplant – Being immunologically smart


1 Department of Nephrology and Renal Transplantation, Medanta Institute of Kidney and Urology, Gurugram, Haryana, India
2 Department of Nephrology, Max Super Speciality Hospital, Ghaziabad, Uttar Pradesh, India

Correspondence Address:
Dr. Pranaw Kumar Jha
Department of Nephrology and Renal Transplantation, Medanta Institute of Kidney and Urology, Medanta – The Medicity, Sector-38, Gurugram - 122 001, Haryana
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijot.ijot_73_20

Get Permissions

Blood group and human leukocyte antigen (HLA) incompatibility are major immunological barriers in renal transplantation. Desensitization and subsequent transplantation improve the longevity and quality of life of these patients when compared to being on a waitlist. For best outcomes, a complete repertoire of immunological workup and an in-depth understanding of these tests are important for choosing the most suitable donor against whom the recipient is least sensitized. We present an interesting case of a sensitized patient who had the option of undergoing renal transplant with either a blood group incompatible mother or a compatible aunt as the prospective donor. Despite the blood group incompatibility, the mother was chosen as the donor in view of the lower strength of anti-HLA antibodies against her. The patient had a successful posttransplant outcome with good graft function at 1 year follow-up. Careful donor selection after detailed immunological workup is important while transplanting sensitized recipients. HLA incompatibility rather than blood group incompatibility should be the deciding factor in such cases.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed240    
    Printed6    
    Emailed0    
    PDF Downloaded55    
    Comments [Add]    

Recommend this journal