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Year : 2021  |  Volume : 15  |  Issue : 1  |  Page : 73-75

Immunomodulation in sepsis - A case report

Department of Nephrology, Star Hospitals; Renown Clinical Services, Hyderabad, Telangana, India

Correspondence Address:
Dr. Rajasekara Chakravarthi Madarasu
Department of Nephrology, Star Hospitals, Road No 10, Banjara Hills, Hyderabad, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijot.ijot_31_20

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Sepsis and septic shock affect anywhere between 100 and 1000/100,000 person-years and 19 per 100,000 person-years depending on the cohort studied, with mortality rates ranging between 20% and 50%. The recently updated Sepsis 3.0 consensus definitions state that sepsis is an infection accompanied by life-threatening organ dysfunction caused by a dysregulated host response. Given the pivotal role of cytokine production in sepsis and post major surgery, it follows that removal of these substances may attenuate the response particularly in the early phase of sepsis.

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