Indian Journal of Transplantation

REVIEW ARTICLE
Year
: 2021  |  Volume : 15  |  Issue : 2  |  Page : 134--138

Challenges of COVID-19 vaccination in the context of transplantation - A narrative review


Hari Shankar Meshram1, Vivek B Kute1, Sanjay K Agarwal2, Manisha Sahay3 
1 Department of Nephrology, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India
2 Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India
3 Department of Nephrology, Osmania General Hospital, Hyderabad, Telangana, India

Correspondence Address:
Prof. Vivek B Kute
Department of Nephrology and Transplantation, Institute of Kidney Diseases and Research Center and Dr. H L Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat
India

Coronavirus disease 19 (COVID-19) vaccination is imperative for preventing disease transmission and combating the associated mortality. Vaccination in the setting of transplantation is a complex issue. Owing to the chronic immunocompromised state in a transplant recipient, the immunogenicity of the vaccines is expected to be attenuated. Immunizing pretransplant patients will also be a challenge, as chronic kidney disease is also an immunocompromised state causing a lower seroconversion rate. The protective immune response generated is also expected to fade earlier. Enumerable psychosocial barriers exist regarding vaccine acceptance and a tender bond between health care providers and patients is essential for the smooth conduct of the vaccination program. The tolerability and safety profile of different available vaccines are reassuring in the general population but more data are needed in transplant communities. In addition, the efficacy data of COVID-19 vaccines are derived from the general population and preliminary reports in transplant patients have shown weakened immune response to vaccination. As of May 2021, Indian government advisories have approved three vaccines: COVIDSHIELD, COVAXIN, and Sputnik. Hence, research on vaccine efficacy with different vaccine constituents, dosing, and intervals is necessary for an effective protocol for vaccination in transplantation.


How to cite this article:
Meshram HS, Kute VB, Agarwal SK, Sahay M. Challenges of COVID-19 vaccination in the context of transplantation - A narrative review.Indian J Transplant 2021;15:134-138


How to cite this URL:
Meshram HS, Kute VB, Agarwal SK, Sahay M. Challenges of COVID-19 vaccination in the context of transplantation - A narrative review. Indian J Transplant [serial online] 2021 [cited 2022 Nov 27 ];15:134-138
Available from: https://www.ijtonline.in/article.asp?issn=2212-0017;year=2021;volume=15;issue=2;spage=134;epage=138;aulast=Meshram;type=0